APIP Antibody (PACO13942)
- SKU:
- PACO13942
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | APIP Antibody (PACO13942) |
抗体コード: | PACO13942 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:500-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human APIP |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Mouse heart tissue, Primary antibody: PACO13942(APIP Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO13942(APIP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria. |
シノニム: | APAF1 interacting protein |
UniProt Protein Function: | MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 4.2.1.109; Amino Acid Metabolism - cysteine and methionine; Apoptosis Chromosomal Location of Human Ortholog: 11p13 Cellular Component: cytoplasm Molecular Function:identical protein binding; 5-methylthioribulose-1-phosphate 4-dehydratase activity; protein binding; zinc ion binding Biological Process: methionine salvage; sulfur amino acid metabolic process; apoptosis; methionine biosynthetic process from S-adenosylmethionine; polyamine metabolic process; negative regulation of apoptosis |
NCBI Summary: | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008] |
UniProt Code: | Q96GX9 |
NCBI GenInfo Identifier: | 74731866 |
NCBI Gene ID: | 51074 |
NCBI Accession: | Q96GX9.1 |
UniProt Secondary Accession: | Q96GX9,Q6PJX6, Q8WVU2, Q96HK2, Q9Y318, A8K9D3, |
UniProt Related Accession: | Q96GX9 |
Molecular Weight: | 242 |
NCBI Full Name: | Methylthioribulose-1-phosphate dehydratase |
NCBI Synonym Full Names: | APAF1 interacting protein |
NCBI Official Symbol: | APIP |
NCBI Official Synonym Symbols: | APIP2; CGI29; hAPIP; CGI-29; MMRP19 |
NCBI Protein Information: | methylthioribulose-1-phosphate dehydratase; APIP; MTRu-1-P dehydratase; APAF1-interacting protein; probable methylthioribulose-1-phosphate dehydratase |
UniProt Protein Name: | Methylthioribulose-1-phosphate dehydratase |
UniProt Synonym Protein Names: | APAF1-interacting protein |
UniProt Gene Name: | APIP |
UniProt Entry Name: | MTNB_HUMAN |