Anti-Ubiquilin-2 Antibody (CAB9568)
- SKU:
- CAB9568
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Frequently bought together:
Description
抗体名: | Anti-Ubiquilin-2 Antibody |
抗体コード: | CAB9568 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human UBQLN2 (NP_038472.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | B cells, NCI-H460, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human UBQLN2 (NP_038472.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAEN GESS GPPR PSRG PAAA QGSA AAPA EPKI IKVT VKTP KEKE EFAV PENS SVQQ FKEA ISKR FKSQ TDQL VLIF AGKI LKDQ DTLI QHGI HDGL TVHL VIKS QNRP QGQS TQPS NAAG TNTT SAST PRSN STPI STNS NPFG LGSL GG |
遺伝子ID: | 29978 |
Uniprot: | Q9UHD9 |
セルラーロケーション: | Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, autophagosome |
計算された分子量: | 65kDa |
観察された分子量: | 70kDa |
同義語: | UBQLN2, ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2 |
バックグラウンド: | This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. |
UniProt Protein Function: | UBQLN2: Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation. Defects in UBQLN2 are the cause of amyotrophic lateral sclerosis type 15 with or without frontotemporal dementia (ALS15). A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: Xp11.21 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein binding Biological Process: ER-associated protein catabolic process; regulation of macroautophagy Disease: Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia |
NCBI Summary: | This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9UHD9 |
NCBI GenInfo Identifier: | 124056593 |
NCBI Gene ID: | 29978 |
NCBI Accession: | Q9UHD9.2 |
UniProt Secondary Accession: | Q9UHD9,O94798, Q5D027, Q9H3W6, Q9HAZ4, |
UniProt Related Accession: | Q9UHD9 |
Molecular Weight: | 65,696 Da |
NCBI Full Name: | Ubiquilin-2 |
NCBI Synonym Full Names: | ubiquilin 2 |
NCBI Official Symbol: | UBQLN2 |
NCBI Official Synonym Symbols: | DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157 |
NCBI Protein Information: | ubiquilin-2 |
UniProt Protein Name: | Ubiquilin-2 |
UniProt Synonym Protein Names: | Chap1; DSK2 homolog; Protein linking IAP with cytoskeleton 2; PLIC-2; hPLIC-2; Ubiquitin-like product Chap1/Dsk2 |
Protein Family: | Ubiquilin |
UniProt Gene Name: | UBQLN2 |
UniProt Entry Name: | UBQL2_HUMAN |
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