Anti-UBIAD1 Antibody (CAB13421)
- SKU:
- CAB13421
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-UBIAD1 Antibody |
抗体コード: | CAB13421 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human UBIAD1 (NP_037451.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | 5637, Mouse kidney |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human UBIAD1 (NP_037451.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MFAY AIQV GSLA IFPL VYAI PLAL STEA ILHS NNTR DMES DREA GIVT LAIL IGPT FSYI LYNT LLFL PYLV FSIL ATHC TISL ALPL LTIP MAFS LERQ FRSQ AFNK LPQR TAKL NLLL GLFY VFGI ILAP AGSL PKI |
遺伝子ID: | 29914 |
Uniprot: | Q9Y5Z9 |
セルラーロケーション: | Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion membrane, Multi-pass membrane protein, Nucleus |
計算された分子量: | 19kDa/36kDa |
観察された分子量: | 37kDa |
同義語: | UBIAD1, SCCD, TERE1 |
バックグラウンド: | This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. |
UniProt Protein Function: | UBIAD1: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Defects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD). SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.5.1.-; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to Golgi membrane; membrane; nucleus Molecular Function:antioxidant activity; prenyltransferase activity; protein binding Biological Process: menaquinone biosynthetic process; ubiquinone biosynthetic process; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; vitamin K biosynthetic process; vitamin K metabolic process Disease: Schnyder Corneal Dystrophy |
NCBI Summary: | This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q9Y5Z9 |
NCBI GenInfo Identifier: | 1057866085 |
NCBI Gene ID: | 29914 |
NCBI Accession: | |
UniProt Secondary Accession: | Q9Y5Z9,Q53GX3, Q5THD4, B3KQG3, |
UniProt Related Accession: | Q9Y5Z9 |
Molecular Weight: | Calculated MW 19kDa/36kDaObserved MW 37kDa |
NCBI Full Name: | ubiA prenyltransferase domain-containing protein 1 isoform 2 |
NCBI Synonym Full Names: | UbiA prenyltransferase domain containing 1 |
NCBI Official Symbol: | UBIAD1 |
NCBI Official Synonym Symbols: | SCCD; TERE1 |
NCBI Protein Information: | ubiA prenyltransferase domain-containing protein 1 |
UniProt Protein Name: | UbiA prenyltransferase domain-containing protein 1 |
UniProt Synonym Protein Names: | Transitional epithelial response protein 1 |
Protein Family: | UbiA prenyltransferase domain-containing protein |
UniProt Gene Name: | UBIAD1 |
UniProt Entry Name: | UBIA1_HUMAN |
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