Anti-TIMP1 Antibody (CAB4959)

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SKU:

CAB4959

Product type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

CLGI

Synonyms:

EPA

Synonyms:

EPO

Synonyms:

HCI

Synonyms:

TIMP

Synonyms:

TIMP-1

Description

Description

UniProt Protein Function:	TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: Xp11.3-p11.23 Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane Molecular Function:metalloendopeptidase inhibitor activity; protein binding; growth factor activity; protease binding; metal ion binding; cytokine activity Biological Process: response to peptide hormone stimulus; platelet activation; extracellular matrix organization and biogenesis; negative regulation of metalloenzyme activity; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; aging; negative regulation of apoptosis
NCBI Summary:	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
UniProt Code:	P01033
NCBI GenInfo Identifier:	135850
NCBI Gene ID:	7076
NCBI Accession:	P01033.1
UniProt Secondary Accession:	P01033,Q14252, Q9UCU1,
UniProt Related Accession:	P01033
Molecular Weight:	23,171 Da
NCBI Full Name:	Metalloproteinase inhibitor 1
NCBI Synonym Full Names:	TIMP metallopeptidase inhibitor 1
NCBI Official Symbol:	TIMP1
NCBI Official Synonym Symbols:	EPA; EPO; HCI; CLGI; TIMP
NCBI Protein Information:	metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
UniProt Protein Name:	Metalloproteinase inhibitor 1
UniProt Synonym Protein Names:	Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
Protein Family:	Metalloproteinase inhibitor
UniProt Gene Name:	TIMP1
UniProt Entry Name:	TIMP1_HUMAN

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