Anti-Thromboxane synthase Antibody (CAB5173)
- SKU:
- CAB5173
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-Thromboxane synthase Antibody |
抗体コード: | CAB5173 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Thromboxane synthase |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | A-549, Mouse lung, Mouse spleen |
免疫原: | A synthesized peptide derived from human Thromboxane synthase |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 6916 |
Uniprot: | P24557 |
セルラーロケーション: | |
計算された分子量: | 54kDa |
観察された分子量: | 60KDa |
同義語: | BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS |
バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
UniProt Protein Function: | TBXAS1: Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD). GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all. Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency). It is characterized by hemorrhagic diathesis. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Isomerase; EC 5.3.99.5 Chromosomal Location of Human Ortholog: 7q34-q35 Cellular Component: endoplasmic reticulum membrane Molecular Function:thromboxane-A synthase activity Biological Process: cyclooxygenase pathway; icosanoid metabolic process Disease: Bleeding Disorder, Platelet-type, 14; Ghosal Hematodiaphyseal Dysplasia |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
UniProt Code: | P24557 |
NCBI GenInfo Identifier: | 254763392 |
NCBI Gene ID: | 6916 |
NCBI Accession: | P24557.3 |
UniProt Secondary Accession: | P24557,O14987, Q16843, Q16844, Q8IUN1, Q96CN2, Q9GZW4 Q9HD77, B4DJG6, E7EMU9, E7EP08, E7ESB5, |
UniProt Related Accession: | P24557 |
Molecular Weight: | 52,287 Da |
NCBI Full Name: | Thromboxane-A synthase |
NCBI Synonym Full Names: | thromboxane A synthase 1 |
NCBI Official Symbol: | TBXAS1 |
NCBI Official Synonym Symbols: | TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14 |
NCBI Protein Information: | thromboxane-A synthase |
UniProt Protein Name: | Thromboxane-A synthase |
UniProt Synonym Protein Names: | Cytochrome P450 5A1 |
Protein Family: | Thromboxane-A synthase |
UniProt Gene Name: | TBXAS1 |
UniProt Entry Name: | THAS_HUMAN |
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