Anti-Syntaxin-16 Antibody (CAB8168)
- SKU:
- CAB8168
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | STX16 Rabbit Polyclonal Antibody |
抗体コード: | CAB8168 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STX16 (NP_001128244.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: | SH-SY5Y, MCF7, SKOV3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STX16 (NP_001128244.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MATR RLTD AFLL LRNN SIQN RQLL AEQV SSHI TSSP LHSR SIAA LADD RMAL VSGI SLDP EAAI GVTK RPPP KWVD GVDE IQYD VGRI KQKM KELA SLHD KHLN RPTL DDSS EEEH AIEI TTQE ITQL FHRC QRAV QALP SRAR ACSE QEGR LLGN VVAS LAQA LQEL STSF RHAQ SGYL KRMK NREE RSQH FFDT SVPL MDDG DDNT LYHR GFTE DQLV LVEQ NTLM VEER EREI RQIV QSIS DLNE IFRD LGAM IVEQ GTVL DRID YNVE QSCI KTED GLKQ LHKA EQYQ KKNR KMLV |
遺伝子ID: | 8675 |
Uniprot: | O14662 |
セルラーロケーション: | Cytoplasm, Golgi apparatus membrane, Single-pass type IV membrane protein |
計算された分子量: | 13kDa/31kDa/34kDa/35kDa/36kDa/37kDa |
観察された分子量: | 44kDa |
同義語: | STX16, SYN16 |
バックグラウンド: | This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. |
UniProt Protein Function: | STX16: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B). Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Belongs to the syntaxin family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 20q13.32 Cellular Component: cytoplasm; focal adhesion; Golgi apparatus; Golgi cisterna; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; SNARE complex; trans-Golgi network; trans-Golgi network membrane Molecular Function:protein binding; SNAP receptor activity; syntaxin binding Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi; vesicle docking; vesicle fusion Disease: Pseudohypoparathyroidism, Type Ib |
NCBI Summary: | This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | O14662 |
NCBI GenInfo Identifier: | 85700437 |
NCBI Gene ID: | 8675 |
NCBI Accession: | O14662.3 |
UniProt Secondary Accession: | O14662,O14661, O14663, O60517, A6NK32, A6NN69, A8MPP0 B7ZBN1, B7ZBN2, B7ZBN3, E1P5M0, E1P607, |
UniProt Related Accession: | O14662 |
Molecular Weight: | 31,074 Da |
NCBI Full Name: | Syntaxin-16 |
NCBI Synonym Full Names: | syntaxin 16 |
NCBI Official Symbol: | STX16 |
NCBI Official Synonym Symbols: | SYN16 |
NCBI Protein Information: | syntaxin-16 |
UniProt Protein Name: | Syntaxin-16 |
Protein Family: | Syntaxin |
UniProt Gene Name: | STX16 |
UniProt Entry Name: | STX16_HUMAN |
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