Anti-STRAP Antibody (CAB19989)[KO Validated]
- SKU:
- CAB19989
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-STRAP Antibody [KO Validated] |
抗体コード: | CAB19989 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human STRAP. |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human STRAP. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 11171 |
Uniprot: | Q9Y3F4 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 38kDa/39kDa |
観察された分子量: | 39KDa |
同義語: | STRAP, MAWD, PT-WD, UNRIP |
バックグラウンド: |
UniProt Protein Function: | STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family. |
UniProt Protein Details: | Protein type:RNA splicing; Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol Molecular Function:protein binding; receptor binding Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation |
UniProt Code: | Q9Y3F4 |
NCBI GenInfo Identifier: | 12643951 |
NCBI Gene ID: | 11171 |
NCBI Accession: | Q9Y3F4.1 |
UniProt Secondary Accession: | Q9Y3F4,Q5TZT4, Q9NTK0, Q9UQC8, B2R5S5, B4DNJ6, |
UniProt Related Accession: | Q9Y3F4 |
Molecular Weight: | 350 |
NCBI Full Name: | Serine-threonine kinase receptor-associated protein |
NCBI Synonym Full Names: | serine/threonine kinase receptor associated protein |
NCBI Official Symbol: | STRAP |
NCBI Official Synonym Symbols: | MAWD; PT-WD; UNRIP |
NCBI Protein Information: | serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats |
UniProt Protein Name: | Serine-threonine kinase receptor-associated protein |
UniProt Synonym Protein Names: | MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD |
Protein Family: | Serine-threonine kinase receptor-associated protein |
UniProt Gene Name: | STRAP |
UniProt Entry Name: | STRAP_HUMAN |