Anti-SOX10 Antibody (CAB8658)

(No reviews yet) Write a Review
SKU:
CAB8658
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DOM
Synonyms:
PCWH
Synonyms:
WS2E
Synonyms:
WS4
Synonyms:
WS4C
€0.00
Frequently bought together:

Description

抗体名:SOX10 Rabbit mAb
抗体コード:CAB8658
サイズ:20uL, 50uL, 100uL
同義語:DOM, PCWH, WS2E, WS4, WS4C
申し込み:WB, IF, IP
反応性:Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human SOX10
申し込み:WB, IF, IP
推奨される希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
反応性:Mouse, Rat
ポジティブサンプル:C6, Mouse brain, Rat brain
免疫原:A synthesized peptide derived from human SOX10
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:6663
Uniprot:P56693
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:60kDa
観察された分子量:60-70kDa
UniProt Protein Function:SOX10: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E). WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C); also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH); also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.
UniProt Protein Details:

Protein type:Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function:identical protein binding; protein binding; transcription coactivator activity

Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter

Disease: Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease; Waardenburg Syndrome, Type 2e; Waardenburg Syndrome, Type 4c

NCBI Summary:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]
UniProt Code:P56693
NCBI GenInfo Identifier:5902104
NCBI Gene ID:6663
NCBI Accession:NP_008872.1
UniProt Secondary Accession:P56693,Q6FHW7, B4DV62,
UniProt Related Accession:P56693
Molecular Weight:49911 MW
NCBI Full Name:transcription factor SOX-10
NCBI Synonym Full Names:SRY-box 10
NCBI Official Symbol:SOX10  
NCBI Official Synonym Symbols:DOM; WS4; PCWH; WS2E; WS4C  
NCBI Protein Information:transcription factor SOX-10
UniProt Protein Name:Transcription factor SOX-10
Protein Family:Transcription factor
UniProt Gene Name:SOX10  
View AllClose

View AllClose

Related Products