Anti-Polyclonal AntibodyPC1 Antibody (CAB14872)
- SKU:
- CAB14872
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-Polyclonal AntibodyPC1 Antibody |
抗体コード: | CAB14872 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human PABPC1 (NP_002559.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, HT-29, HeLa, Mouse brain, Rat lung |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human PABPC1 (NP_002559.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | VTEM NGRI VATK PLYV ALAQ RKEE RQAH LTNQ YMQR MASV RAVP NPVI NPYQ PAPP SGYF MAAI PQTQ NRAA YYPP SQIA QLRP SPRW TAQG ARPH PFQN M |
遺伝子ID: | 26986 |
Uniprot: | P11940 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 61kDa/70kDa |
観察された分子量: | 71kDa |
同義語: | PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1 |
バックグラウンド: | This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes. |
UniProt Protein Function: | PABP 1: poly(A) binding protein 1. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Shuttles between the cytoplasm and the nucleus. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. A potential substrate in MAPKAP kinase 2-induced mRNA stabilization. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Spliceosome; Translation; Motility/polarity/chemotaxis; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 8q22.2-q23 Cellular Component: focal adhesion; membrane; stress granule; cytoplasm; ribonucleoprotein complex; nucleus; cytosol Molecular Function:protein C-terminus binding; protein binding; translation activator activity; nucleotide binding; poly(U) binding; poly(A) binding Biological Process: nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; cellular protein metabolic process; translation; positive regulation of translation; mRNA stabilization; mRNA catabolic process, nonsense-mediated decay; translational initiation; mRNA polyadenylation; gene expression; RNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay |
NCBI Summary: | This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010] |
UniProt Code: | P11940 |
NCBI GenInfo Identifier: | 3183544 |
NCBI Gene ID: | 26986 |
NCBI Accession: | P11940.2 |
UniProt Related Accession: | P11940 |
Molecular Weight: | |
NCBI Full Name: | Polyadenylate-binding protein 1 |
NCBI Synonym Full Names: | poly(A) binding protein cytoplasmic 1 |
NCBI Official Symbol: | PABPC1 |
NCBI Official Synonym Symbols: | PAB1; PABP; PABP1; PABPC2; PABPL1 |
NCBI Protein Information: | polyadenylate-binding protein 1 |
UniProt Protein Name: | Polyadenylate-binding protein 1 |
UniProt Gene Name: | PABPC1 |
UniProt Entry Name: | PABP1_HUMAN |