Anti-PLA2G2A 抗体 (CAB1234)

抗体名:	Anti-PLA2G2A Antibody
抗体コード:	CAB1234
抗体サイズ:	20uL, 50uL, 100uL
申し込み:	WB
反応性:	Human, Mouse
宿主種:	Rabbit
免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-144 of human PLA2G2A (NP_001155201.1).

申し込み:	WB
推奨希釈:	WB 1:500 - 1:2000
反応性:	Human, Mouse
ポジティブサンプル:	BT-474, Mouse intestine

免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-144 of human PLA2G2A (NP_001155201.1).
精製方法:	Affinity purification
ストレージバッファ:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:	IgG
順序:	NLVN FHRM IKLT TGKE AALS YGFY GCHC GVGG RGSP KDAT DRCC VTHD CCYK RLEK RGCG TKFL SYKF SNSG SRIT CAKQ DSCR SQLC ECDK AAAT CFAR NKTT YNKK YQYY SNKH CRGS TPRC
遺伝子ID:	5320
Uniprot:	P14555
セルラーロケーション:	Membrane, Peripheral membrane protein
計算された分子量:	16kDa
観察された分子量:	18kDa

同義語:

PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2

バックグラウンド:

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.

UniProt Protein Function:	PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.
UniProt Protein Details:	Protein type:Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Vesicle; Endoplasmic reticulum; Phospholipase; EC 3.1.1.4; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Lipid Metabolism - alpha-linolenic acid; Mitochondrial; Secreted; Lipid Metabolism - linoleic acid Chromosomal Location of Human Ortholog: 1p35 Cellular Component: extracellular space; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; extracellular region; secretory granule Molecular Function:phospholipase A2 activity; calcium-dependent phospholipase A2 activity; phospholipid binding; calcium ion binding Biological Process: defense response to Gram-positive bacterium; phosphatidic acid metabolic process; somatic stem cell maintenance; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process; positive regulation of inflammatory response; negative regulation of epithelial cell proliferation Disease: Colorectal Cancer
NCBI Summary:	The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:	P14555
NCBI GenInfo Identifier:	129483
NCBI Gene ID:	5320
NCBI Accession:	P14555.2
UniProt Secondary Accession:	P14555,Q6DN24, Q6IBD9, Q9UCD2, A8K5I7,
UniProt Related Accession:	P14555
Molecular Weight:	144
NCBI Full Name:	Phospholipase A2, membrane associated
NCBI Synonym Full Names:	phospholipase A2, group IIA (platelets, synovial fluid)
NCBI Official Symbol:	PLA2G2A
NCBI Official Synonym Symbols:	MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
NCBI Protein Information:	phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2
UniProt Protein Name:	Phospholipase A2, membrane associated
UniProt Synonym Protein Names:	GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A
Protein Family:	Phospholipase
UniProt Gene Name:	PLA2G2A
UniProt Entry Name:	PA2GA_HUMAN

Western blot analysis of extracts of various cell lines, using PLA2G2A antibody (CAB1234) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

ELISA Kits

Human PLA2G2A / MOM1 / Phospholipase A2, membrane associated ELISA Kit

Human PLA2G2A (Phospholipase A2, Group II A) CLIA Kit (HUES01232)

Human Phospholipase A2, membrane associated (PLA2G2A) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)