| UniProt Protein Function: | SMAD5: transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm; transcription factor complex; protein complex; cytoplasm; integral to membrane; intracellular; nucleus; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding; metal ion binding; receptor signaling protein activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Biological Process: Mullerian duct regression; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; positive regulation of osteoblast differentiation; ureteric bud development; transforming growth factor beta receptor signaling pathway; cartilage development; erythrocyte differentiation; cardiac muscle contraction; osteoblast fate commitment |
| NCBI Summary: | The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q99717 |
| NCBI GenInfo Identifier: | 13959566 |
| NCBI Gene ID: | 4090 |
| NCBI Accession: | Q99717.1 |
| UniProt Secondary Accession: | Q99717,O14688, Q15798, Q9UQA1, |
| UniProt Related Accession: | Q99717 |
| Molecular Weight: | 52,258 Da |
| NCBI Full Name: | Mothers against decapentaplegic homolog 5 |
| NCBI Synonym Full Names: | SMAD family member 5 |
| NCBI Official Symbol: | SMAD5 |
| NCBI Official Synonym Symbols: | DWFC; JV5-1; MADH5 |
| NCBI Protein Information: | mothers against decapentaplegic homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5 |
| UniProt Protein Name: | Mothers against decapentaplegic homolog 5 |
| UniProt Synonym Protein Names: | JV5-1; SMAD family member 5; SMAD 5; Smad5; hSmad5 |
| Protein Family: | SMAD5 antisense gene protein |
| UniProt Gene Name: | SMAD5 |
| UniProt Entry Name: | SMAD5_HUMAN |
