Anti-Phospho-Rptor-S791 Antibody (CABP0868)
- SKU:
- CABP0868
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-Rptor-S791 Antibody |
| 抗体コード: | CABP0868 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S791 of mouse Rptor |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S791 of mouse Rptor |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 74370 |
| Uniprot: | Q8K4Q0 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic granule, Lysosome |
| 計算された分子量: | 149kDa |
| 観察された分子量: |
| 同義語: | 4932417H02Rik, Rap, Raptor, mKIAA1303, Rptor, RPTOR, KOG1, Mip1 |
| バックグラウンド: | This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Raptor: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Interacts with MTOR. Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Binds directly to 4EBP1 and RPS6KB1 independently of its association with MTOR. Binds preferentially to poorly or non-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation. Forms a complex with MTOR under both leucine-rich and -poor conditions. Interacts with ULK1 in a nutrient-dependent manner; the interaction is reduced during starvation. Interacts (when phosphorylated by AMPK) with 14-3-3 protein, leading to inhibit its activity. Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Belongs to the WD repeat RAPTOR family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Cellular Component: nucleoplasm; cell soma; intracellular membrane-bound organelle; lysosomal membrane; lysosome; cytoplasm; dendrite Molecular Function:protein binding; protein complex binding; protein kinase binding Biological Process: cellular response to nutrient levels; TOR signaling pathway; regulation of phosphorylation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of endothelial cell proliferation; cell growth; regulation of cell size; positive regulation of TOR signaling pathway |
| NCBI Summary: | This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | Q8K4Q0 |
| NCBI GenInfo Identifier: | 46577497 |
| NCBI Gene ID: | 74370 |
| NCBI Accession: | Q8K4Q0.1 |
| UniProt Related Accession: | Q8K4Q0 |
| Molecular Weight: | 149kDa |
| NCBI Full Name: | Regulatory-associated protein of mTOR |
| NCBI Synonym Full Names: | regulatory associated protein of MTOR, complex 1 |
| NCBI Official Symbol: | Rptor |
| NCBI Official Synonym Symbols: | Rap; Raptor; mKIAA1303; 4932417H02Rik |
| NCBI Protein Information: | regulatory-associated protein of mTOR |
| UniProt Protein Name: | Regulatory-associated protein of mTOR |
| UniProt Synonym Protein Names: | p150 target of rapamycin (TOR)-scaffold protein |
| Protein Family: | Regulatory-associated protein |
| UniProt Gene Name: | Rptor |
| UniProt Entry Name: | RPTOR_MOUSE |
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