Anti-Phospho-PPP1R12A/PPP1R12B/PPP1R12C-T696 Antibody (CABP1164)

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SKU:
CABP1164
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-Phospho-PPP1R12A/PPP1R12B/PPP1R12C-T696 Antibody
抗体コード:CABP1164
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A synthetic phosphorylated peptide around T696 of human PPP1R12A/PPP1R12B/PPP1R12C.
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:Jurkat
免疫原:A synthetic phosphorylated peptide around T696 of human PPP1R12A/PPP1R12B/PPP1R12C.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:4659/4660/54776
Uniprot:O14974/O60237/Q9BZL4
セルラーロケーション:
計算された分子量:
観察された分子量:140kDa
Anti-Phospho-PPP1R12A/PPP1R12B/PPP1R12C-T696 Antibody (CABP1164)Western blot - Phospho-PPP1R12A/PPP1R12B/PPP1R12C-T696 Rabbit pAb (CABP1164)
同義語:
バックグラウンド:Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
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