Anti-Phospho-MYH9-S1943 pAb Antibody (CABP0802)
- SKU:
- CABP0802
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
抗体名: | Anti-Phospho-MYH9-S1943 Antibody |
抗体コード: | CABP0802 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic phosphorylated peptide around S1943 of human MYH9 (NP_002464.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | A synthetic phosphorylated peptide around S1943 of human MYH9 (NP_002464.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DGSD E |
遺伝子ID: | 4627 |
Uniprot: | P35579 |
セルラーロケーション: | Cytoplasm, cell cortex, cytoskeleton |
計算された分子量: | 159kDa/226kDa |
観察された分子量: | 250kDa |
同義語: | MYH9, BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, myosin-9 |
バックグラウンド: | This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. |
UniProt Protein Function: | MYH9: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: actin cytoskeleton; actomyosin; cleavage furrow; contractile ring; cytoplasm; cytosol; focal adhesion; immunological synapse; integrin complex; leading edge; membrane; myosin II complex; nucleus; plasma membrane; protein complex; ruffle; signalosome; stress fiber; uropod Molecular Function:actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; microfilament motor activity; protein anchor; protein binding; protein domain specific binding; protein homodimerization activity Biological Process: actin cytoskeleton reorganization; actin filament-based movement; actomyosin structure organization and biogenesis; angiogenesis; blood vessel endothelial cell migration; cytokinesis; membrane protein ectodomain proteolysis; monocyte differentiation; phagocytosis, engulfment; platelet formation; protein transport; regulation of cell shape Disease: Deafness, Autosomal Dominant 17; Epstein Syndrome; Fechtner Syndrome; Macrothrombocytopenia And Progressive Sensorineural Deafness; May-hegglin Anomaly; Sebastian Syndrome |
NCBI Summary: | This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011] |
UniProt Code: | P35579 |
NCBI GenInfo Identifier: | 6166599 |
NCBI Gene ID: | 4627 |
NCBI Accession: | P35579.4 |
UniProt Secondary Accession: | P35579,O60805, Q60FE2, Q86T83, A8K6E4, |
UniProt Related Accession: | P35579 |
Molecular Weight: | 159,864 Da |
NCBI Full Name: | Myosin-9 |
NCBI Synonym Full Names: | myosin, heavy chain 9, non-muscle |
NCBI Official Symbol: | MYH9 |
NCBI Official Synonym Symbols: | MHA; FTNS; EPSTS; BDPLT6; DFNA17; NMMHCA; NMHC-II-A; NMMHC-IIA |
NCBI Protein Information: | myosin-9 |
UniProt Protein Name: | Myosin-9 |
UniProt Synonym Protein Names: | Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; Non-muscle myosin heavy chain A; NMMHC-A; Non-muscle myosin heavy chain IIa; NMMHC II-a; NMMHC-IIA |
Protein Family: | Myosin |
UniProt Gene Name: | MYH9 |
UniProt Entry Name: | MYH9_HUMAN |