Anti-Phospho-MAP3K5-T845 Antibody (CABP1215)

(No reviews yet) Write a Review
SKU:
CABP1215
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
A
Synonyms:
AS
Synonyms:
ASK
Synonyms:
ASK1
Synonyms:
Mekk5
Synonyms:
MAPKKK5
Synonyms:
7420452D20Rik
€0.00
Frequently bought together:

Description

抗体名:Phospho-MAP3K5-T845 Rabbit pAb
抗体コード:CABP1215
サイズ:50uL, 100uL
同義語:A, AS, ASK, ASK1, Mekk5, MAPKKK5, 7420452D20Rik
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A phospho specific peptide corresponding to residues surrounding T845 of human MAP3K5.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:293T
免疫原:A phospho specific peptide corresponding to residues surrounding T845 of human MAP3K5.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:26408
Uniprot:O35099
観察された分子量:155KDa
UniProt Protein Function:ASK1: a MAP kinase kinase kinase of the STE11 family, apoptosis signal-regulating kinase 1 (ASK1) plays essential roles in stress-induced apoptosis. Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). In turn, ASK1 phosphorylates and activates two different subgroups of MAP kinase kinases, MKK4/SEK1 and MKK3/MKK6, which in turn activate stress-activated protein kinases (JNKs) and p38 subgroups of MAP kinases, respectively. Overexpression activates JNK and p38 and induces apoptosis in several cell types through signals involving the mitochondrial cell death pathway. Embryonic fibroblasts or primary neurons derived from ASK1-/- mice are resistant to stress-induced JNK and p38 activation as well as cell death. Oxidative stress induces the activation of ASK1, which correlate with ASK1 activity and ASK1-dependent apoptosis. Required for the innate immune response, which is essential for host defense against a wide range of pathogens.
UniProt Protein Details:

Protein type:EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE11 family

Cellular Component: cytoplasm; cytosol; external side of plasma membrane

Molecular Function:ATP binding; magnesium ion binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding

Biological Process: activation of MAPK activity; activation of MAPKK activity; induction of apoptosis by oxidative stress; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation

UniProt Code:O35099
NCBI GenInfo Identifier:341941007
NCBI Gene ID:26408
NCBI Accession:O35099.3
UniProt Secondary Accession:O35099,Q14AY5,
UniProt Related Accession:O35099
Molecular Weight:154,512 Da
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 5
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 5
NCBI Official Symbol:Map3k5  
NCBI Official Synonym Symbols:ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 5
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 5
UniProt Synonym Protein Names:Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
Protein Family:Mitogen-activated protein kinase kinase kinase
UniProt Gene Name:Map3k5  
UniProt Entry Name:M3K5_MOUSE
View AllClose

View AllClose

Related Products