Anti-Phospho-AKT1-S473+AKT2-S474+AKT3-S472 Antibody (CABP1068)
- SKU:
- CABP1068
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-Phospho-AKT1-S473+AKT2-S474+AKT3-S472 Antibody |
抗体コード: | CABP1068 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A phospho synthetic peptide corresponding to residues surrounding S473/S474/S472 of human AKT1/AKT2/AKT3. |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NIH/3T3, C6 |
免疫原: | A phospho synthetic peptide corresponding to residues surrounding S473/S474/S472 of human AKT1/AKT2/AKT3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 207/208/10000 |
Uniprot: | P31749/P31751/Q9Y243 |
セルラーロケーション: | |
計算された分子量: | 48kDa/55kDa/51kDa/54kDa |
観察された分子量: | 60kDa |
同義語: | AKT1/AKT2/AKT3 |
バックグラウンド: | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] |