Anti-PHKG2 Antibody (CAB19934)[KO Validated]
- SKU:
- CAB19934
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PHKG2 Antibody [KO Validated] |
抗体コード: | CAB19934 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human PHKG2. |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human PHKG2. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5261 |
Uniprot: | P15735 |
セルラーロケーション: | |
計算された分子量: | 43kDa/46kDa |
観察された分子量: | 42KDa |
同義語: | PHKG2, GSD9C |
バックグラウンド: | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
UniProt Protein Function: | PHKG2: a Ca(2 )/calmodulin-dependent protein kinase of the PHK family. Phosphorylase kinase is a polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin. This isozyme may regulate glycogeneolysis in the testis. |
UniProt Protein Details: | Protein type:EC 2.7.11.19; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; PHK family Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: phosphorylase kinase complex; cytosol Molecular Function:calmodulin binding; phosphorylase kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; ATP binding Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen biosynthetic process; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; protein amino acid phosphorylation; positive regulation of glycogen catabolic process Disease: Glycogen Storage Disease Ixc |
NCBI Summary: | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] |
UniProt Code: | P15735 |
NCBI GenInfo Identifier: | 125536 |
NCBI Gene ID: | 5261 |
NCBI Accession: | P15735.1 |
UniProt Secondary Accession: | P15735,P11800, A8K0C7, B4DEB7, E9PEU3, |
UniProt Related Accession: | P15735 |
Molecular Weight: | 406 |
NCBI Full Name: | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
NCBI Synonym Full Names: | phosphorylase kinase, gamma 2 (testis) |
NCBI Official Symbol: | PHKG2 |
NCBI Official Synonym Symbols: | GSD9C |
NCBI Protein Information: | phosphorylase b kinase gamma catalytic chain, liver/testis isoform; PSK-C3; PHK-gamma-T; PHK-gamma-LT; phosphorylase kinase subunit gamma-2; serine/threonine-protein kinase PHKG2; Phosphorylase kinase, gamma 2 (testis/liver); phosphorylase b kinase gamma catalytic chain, testis/liver isoform |
UniProt Protein Name: | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
UniProt Synonym Protein Names: | PSK-C3; Phosphorylase kinase subunit gamma-2 |
Protein Family: | Phosphorylase b kinase |
UniProt Gene Name: | PHKG2 |
UniProt Entry Name: | PHKG2_HUMAN |