Anti-p70 S6 kinase Antibody (CAB15719)
- SKU:
- CAB15719
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-p70 S6 kinase Antibody |
抗体コード: | CAB15719 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 361-525 of human RPS6KB1 (NP_003152.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 361-525 of human RPS6KB1 (NP_003152.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LARK VEPP FKPL LQSE EDVS QFDS KFTR QTPV DSPD DSTL SESA NQVF LGFT YVAP SVLE SVKE KFSF EPKI RSPR RFIG SPRT PVSP VKFS PGDF WGRG ASAS TANP QTPV EYPM ETSG IEQM DVTM SGEA SAPL PIRQ PNSG PYKK QAFP MISK RPEH LRMN L |
遺伝子ID: | 6198 |
Uniprot: | P23443 |
セルラーロケーション: | Cell junction, Cytoplasm, Mitochondrion outer membrane, Mitochondrion, Nucleus, synapse, synaptosome |
計算された分子量: | 51kDa/52kDa/56kDa/59kDa |
観察された分子量: |
同義語: | PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, P70 S6K, RPS6KB1, p70S6KA |
バックグラウンド: | This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. |
UniProt Protein Function: | p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; AGC group; RSK family; p70 subfamily Chromosomal Location of Human Ortholog: 17q23.1 |
NCBI Summary: | This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] |
UniProt Code: | P23443 |
NCBI GenInfo Identifier: | 54041234 |
NCBI Gene ID: | 6198 |
NCBI Accession: | P23443.2 |
UniProt Secondary Accession: | P23443,Q7Z721, B2R779, B4DLT4, B4DTG1, E7ESB8, F6UYM1 |
UniProt Related Accession: | P23443 |
Molecular Weight: | 525 |
NCBI Full Name: | Ribosomal protein S6 kinase beta-1 |
NCBI Synonym Full Names: | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
NCBI Official Symbol: | RPS6KB1 |
NCBI Official Synonym Symbols: | S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha |
NCBI Protein Information: | ribosomal protein S6 kinase beta-1; p70 S6 kinase, alpha; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A |
UniProt Protein Name: | Ribosomal protein S6 kinase beta-1 |
UniProt Synonym Protein Names: | 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA |
Protein Family: | Ribosomal protein S6 kinase |
UniProt Gene Name: | RPS6KB1 |
UniProt Entry Name: | KS6B1_HUMAN |
Immunofluorescence analysis of U2OS cells using p70 S6 kinase antibody (CAB15719) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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