Anti-NEIL-1 Antibody (CAB5828)
- SKU:
- CAB5828
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | NEIL1 Rabbit Polyclonal Antibody |
抗体コード: | CAB5828 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-476 of human NEIL1 (NP_001243481.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, MCF7, Mouse spleen, Rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-476 of human NEIL1 (NP_001243481.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FYTA PPGP RLAL CFVD IRRF GRWD LGGK WQPG RGPC VLQE YQQF RENV LRNL ADKA FDRP ICEA LLDQ RFFN GIGN YLRA EILY RLKI PPFE KARS VLEA LQQH RPSP ELTL SQKI RTKL QNPD LLEL CHSV PKEV VQLG GKGY GSES GEED FAAF RAWL RCYG MPGM SSLQ DRHG RTIW FQGD PGPL APKG RKSR KKKS KATQ LSPE DRVE DALP PSKA PSRT RRAK RDLP KRTA TQRP EGTS LQQD PEAP TVPK KGRR KGRQ AASG HCRP RKVK ADIP SLEP EGTS AS |
遺伝子ID: | 79661 |
Uniprot: | Q96FI4 |
セルラーロケーション: | Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
計算された分子量: | 43kDa |
観察された分子量: | 44KDa |
同義語: | NEIL1, FPG1, NEI1, hFPG1 |
バックグラウンド: | This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | NEIL1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Belongs to the FPG family. |
UniProt Protein Details: | Protein type:DNA repair, damage; Hydrolase; EC 4.2.99.18; Lyase Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; hydrolase activity, acting on glycosyl bonds; protein C-terminus binding Biological Process: base-excision repair; depyrimidination; negative regulation of nuclease activity; response to oxidative stress |
NCBI Summary: | This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q96FI4 |
NCBI GenInfo Identifier: | 56404654 |
NCBI Gene ID: | 79661 |
NCBI Accession: | Q96FI4.3 |
UniProt Secondary Accession: | Q96FI4,Q6ZRA7, Q86XW7, Q9H6C3, D3DW75, |
UniProt Related Accession: | Q96FI4 |
Molecular Weight: | 43,684 Da |
NCBI Full Name: | Endonuclease 8-like 1 |
NCBI Synonym Full Names: | nei like DNA glycosylase 1 |
NCBI Official Symbol: | NEIL1 |
NCBI Official Synonym Symbols: | FPG1; NEI1; hFPG1 |
NCBI Protein Information: | endonuclease 8-like 1 |
UniProt Protein Name: | Endonuclease 8-like 1 |
UniProt Synonym Protein Names: | DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; FPG1; Nei homolog 1; NEH1; Nei-like protein 1 |
Protein Family: | Endonuclease |
UniProt Gene Name: | NEIL1 |
UniProt Entry Name: | NEIL1_HUMAN |
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