Anti-MTA2 [KO Validated] Antibody (CAB4624)

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SKU:
CAB4624
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Application:
WB
Application:
IHC
Application:
IF
Application:
IP
Application:
ChIP
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MTA1L1
Synonyms:
PID
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Description

抗体名:[KO Validated] MTA2 Rabbit mAb
抗体コード:CAB4624
サイズ:20uL, 50uL, 100uL
同義語:MTA1L1, PID
申し込み:WB, IHC, IF, IP, ChIP
反応性:Human
宿主種:Rabbit
免疫原:A synthesized peptide derived from human MTA2
申し込み:WB, IHC, IF, IP, ChIP
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 ChIP 1:20 - 1:200
反応性:Human
ポジティブサンプル:293T
免疫原:A synthesized peptide derived from human MTA2
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:9219
Uniprot:O94776
セルラーロケーション:Nucleus
計算された分子量:75kDa
観察された分子量:75KDa
UniProt Protein Function:MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Deacetylase

Chromosomal Location of Human Ortholog: 11q12-q13.1

Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; histone deacetylase complex; nuclear chromatin; NuRD complex

Molecular Function:protein binding; nucleosomal DNA binding; zinc ion binding; histone deacetylase activity; transcription factor activity

Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; ATP-dependent chromatin remodeling; DNA methylation; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
UniProt Code:O94776
NCBI GenInfo Identifier:29840793
NCBI Gene ID:9219
NCBI Accession:O94776.1
UniProt Related Accession:O94776
Molecular Weight:Observed Molecular Weight: (Observed)75kD.Predicted Molecular Weight: (Calculated)75kDa.
NCBI Full Name:Metastasis-associated protein MTA2
NCBI Synonym Full Names:metastasis associated 1 family member 2
NCBI Official Symbol:MTA2  
NCBI Official Synonym Symbols:PID; MTA1L1  
NCBI Protein Information:metastasis-associated protein MTA2
UniProt Protein Name:Metastasis-associated protein MTA2
UniProt Synonym Protein Names:Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex
Protein Family:Metastasis-associated protein
UniProt Gene Name:MTA2  
UniProt Entry Name:MTA2_HUMAN
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