Anti-MCC Antibody (CAB13857)
- SKU:
- CAB13857
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-MCC Antibody |
抗体コード: | CAB13857 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MCC (NP_002378.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, HT-29, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MCC (NP_002378.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MNSG VAMK YGND SSAE LSEL HSAA LASL KGDI VELN KRLQ QTER ERDL LEKK LAKA QCEQ SHLM REHE DVQE RTTL RYEE RITE LHSV IAEL NKKI DRLQ GTTI REED EYSE LRSE LSQS QHEV NEDS RSMD QDQT SVSI PENQ STMV TADM DNCS DLNS ELQR VLTG LENV VCGR KKSS CSLS VAEV DRHI EQLT TASE HCDL AIKT VEEI EGVL GRDL YPNL AEER SRWE KELA GLRE ENES LTAM LCSK EEEL NRTK ATMN AIRE ERDR LRRR VREL QTRL QSVQ ATGP SSPG RLTS |
遺伝子ID: | 4163 |
Uniprot: | P23508 |
セルラーロケーション: | Cell membrane, Cell projection, Cytoplasm, Nucleus, lamellipodium |
計算された分子量: | 93kDa/113kDa |
観察された分子量: | 120kDa |
同義語: | MCC, MCC1 |
バックグラウンド: | This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | MCC: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Belongs to the MCC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 5q21 Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding; receptor activity Biological Process: establishment of protein localization; negative regulation of epithelial cell proliferation; signal transduction |
NCBI Summary: | This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P23508 |
NCBI GenInfo Identifier: | 317373352 |
NCBI Gene ID: | 4163 |
NCBI Accession: | P23508.2 |
UniProt Secondary Accession: | P23508,Q6ZR04, D3DT05, |
UniProt Related Accession: | P23508 |
Molecular Weight: | 113,279 Da |
NCBI Full Name: | Colorectal mutant cancer protein |
NCBI Synonym Full Names: | mutated in colorectal cancers |
NCBI Official Symbol: | MCC |
NCBI Official Synonym Symbols: | MCC1 |
NCBI Protein Information: | colorectal mutant cancer protein |
UniProt Protein Name: | Colorectal mutant cancer protein |
Protein Family: | Colorectal mutant cancer protein |
UniProt Gene Name: | MCC |
UniProt Entry Name: | CRCM_HUMAN |
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