Anti-LTA4H Antibody (CAB19939)[KO Validated]
- SKU:
- CAB19939
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-LTA4H Antibody [KO Validated] |
抗体コード: | CAB19939 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human LTA4H. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human LTA4H. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 4048 |
Uniprot: | P09960 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 57kDa/59kDa/66kDa/69kDa |
観察された分子量: | 70KDa |
同義語: | LTA4H |
バックグラウンド: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:peptidase activity; leukotriene-A4 hydrolase activity; metallopeptidase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity Biological Process: leukotriene biosynthetic process; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; proteolysis; inflammatory response |
NCBI Summary: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | P09960 |
NCBI GenInfo Identifier: | 126353 |
NCBI Gene ID: | 4048 |
NCBI Accession: | P09960.2 |
UniProt Related Accession: | P09960 |
Molecular Weight: | ~ 69kDa |
NCBI Full Name: | Leukotriene A-4 hydrolase |
NCBI Synonym Full Names: | leukotriene A4 hydrolase |
NCBI Official Symbol: | LTA4H |
NCBI Protein Information: | leukotriene A-4 hydrolase |
UniProt Protein Name: | Leukotriene A-4 hydrolase |
UniProt Synonym Protein Names: | Leukotriene A(4) hydrolase |
Protein Family: | Leukotriene A-4 hydrolase |
UniProt Gene Name: | LTA4H |
UniProt Entry Name: | LKHA4_HUMAN |