Anti-LTA Antibody (RACO0201)
- SKU:
- RACO0201
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
商品名: | LTA Antibody |
Product SKU: | RACO0201 |
サイズ: | 50ul |
宿主種: | Human |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | A synthesized peptide derived from human LTA |
憲法: | Liquid |
ストレージバッファ: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Affinity-chromatography |
抗体のクローン性: | Monoclonal |
アイソタイプ: | Rabbit IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
シノニム: | Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1 |
UniProt Protein Function: | LTA: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS). PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Cytokine; Apoptosis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: extracellular space; membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: response to drug; positive regulation of humoral immune response mediated by circulating immunoglobulin; apoptosis; positive regulation of apoptosis; response to lipopolysaccharide; signal transduction; lymph node development; humoral immune response; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; cell-cell signaling; negative regulation of fibroblast proliferation; response to hypoxia; positive regulation of chronic inflammatory response to antigenic stimulus; response to nutrient Disease: Psoriatic Arthritis, Susceptibility To; Myocardial Infarction, Susceptibility To; Leprosy, Susceptibility To, 4 |
NCBI Summary: | The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | P01374 |
NCBI GenInfo Identifier: | 135940 |
NCBI Gene ID: | 4049 |
NCBI Accession: | P01374.2 |
UniProt Secondary Accession: | P01374,Q8N4C3, Q9UKS8, |
UniProt Related Accession: | P01374 |
Molecular Weight: | 22,297 Da |
NCBI Full Name: | Lymphotoxin-alpha |
NCBI Synonym Full Names: | lymphotoxin alpha |
NCBI Official Symbol: | LTA |
NCBI Official Synonym Symbols: | LT; TNFB; TNFSF1 |
NCBI Protein Information: | lymphotoxin-alpha; LT-alpha; TNF-beta; TNF superfamily, member 1; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1 |
UniProt Protein Name: | Lymphotoxin-alpha |
UniProt Synonym Protein Names: | TNF-beta; Tumor necrosis factor ligand superfamily member 1 |
Protein Family: | Lymphotoxin |
UniProt Gene Name: | LTA |
UniProt Entry Name: | TNFB_HUMAN |