Anti-Lamin B2 Antibody (CAB5001)

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SKU:
CAB5001
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EPM9
Synonyms:
LAMB2
Synonyms:
LMN2
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Description

I抗体名:Lamin B2 Rabbit mAb
抗体コード:CAB5001
サイズ:20uL, 50uL, 100uL
同義語:EPM9, LAMB2, LMN2
申し込み:WB, IHC, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human Lamin B2
申し込み:WB, IHC, IF
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, RD, Jurkat
免疫原:A synthesized peptide derived from human Lamin B2
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:84823
Uniprot:Q03252
セルラーロケーション:Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane
計算された分子量:68kDa
観察された分子量:68KDa
UniProt Protein Function:Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: lamin filament; nuclear inner membrane

Molecular Function:structural molecule activity

Disease: Lipodystrophy, Partial, Acquired, Susceptibility To

UniProt Code:Q03252
NCBI GenInfo Identifier:23503078
NCBI Gene ID:
NCBI Accession:Q03252.3
Molecular Weight:
NCBI Full Name:Lamin-B2
UniProt Protein Name:Lamin-B2
Protein Family:Lamin
UniProt Gene Name:LMNB2  
UniProt Entry Name:LMNB2_HUMAN
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