Anti-KMT5C Antibody (CAB16235)[KO Validated]
- SKU:
- CAB16235
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-KMT5C Antibody [KO Validated] |
抗体コード: | CAB16235 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KMT5C (NP_116090.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | 293T, HeLa, K-562, SH-SY5Y, Mouse brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KMT5C (NP_116090.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FLPE SGFT ILPC TRYS METN GAKI VSTR AWKK NEKL ELLV GCIA ELRE ADEG LLRA GEND FSIM YSTR KRSA QLWL GPAA FINH DCKP NCKF VPAD GNAA C |
遺伝子ID: | 84787 |
Uniprot: | Q86Y97 |
セルラーロケーション: | Chromosome, Nucleus |
計算された分子量: | 10kDa/52kDa |
観察された分子量: | 52kDa |
同義語: | KMT5C, SUV420H2, Suv4-20h2 |
バックグラウンド: | SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20). |
UniProt Protein Function: | SUV420H2: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 19q13.42 Cellular Component: centric heterochromatin; nuclear heterochromatin; nucleoplasm Molecular Function:protein binding |
NCBI Summary: | SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009] |
UniProt Code: | Q86Y97 |
NCBI GenInfo Identifier: | 74727906 |
NCBI Gene ID: | 84787 |
NCBI Accession: | Q86Y97.1 |
UniProt Secondary Accession: | Q86Y97,Q8WZ10, Q9BRZ6, |
UniProt Related Accession: | Q86Y97 |
Molecular Weight: | 10,821 Da |
NCBI Full Name: | Histone-lysine N-methyltransferase KMT5C |
NCBI Synonym Full Names: | lysine methyltransferase 5C |
NCBI Official Symbol: | KMT5C |
NCBI Official Synonym Symbols: | SUV420H2 |
NCBI Protein Information: | histone-lysine N-methyltransferase KMT5C |
UniProt Protein Name: | Histone-lysine N-methyltransferase KMT5C |
UniProt Synonym Protein Names: | Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C |
UniProt Gene Name: | KMT5C |
UniProt Entry Name: | KMT5C_HUMAN |
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