Anti-JNK1/2/3 Antibody (CAB18678)
- SKU:
- CAB18678
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-JNK1/2/3 Antibody |
抗体コード: | CAB18678 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human JNK1/2/3. |
申し込み: | WB IHC IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, Mouse brain, Rat brain |
免疫原: | Recombinant protein of human JNK1/2/3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5599/5601/5602 |
Uniprot: | P45983/P45984/P53779 |
セルラーロケーション: | |
計算された分子量: | 35kDa/44kDa/48kDa/27kDa/52kDa |
観察された分子量: | 46kDa/54kDa |
同義語: | |
バックグラウンド: | JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1, JNK2, and JNK3 |