Anti-IL-18 Antibody (CAB1115)[KO Validated]
- SKU:
- CAB1115
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
抗体名: | [KO Validated] IL18 Rabbit Polyclonal Antibody |
抗体コード: | CAB1115 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-193 of human IL18 (NP_001553.1). |
申し込み: | WB IP |
推奨希釈: | WB 1:500 - 1:2000 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-193 of human IL18 (NP_001553.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | YFGK LESK LSVI RNLN DQVL FIDQ GNRP LFED MTDS DCRD NAPR TIFI ISMY KDSQ PRGM AVTI SVKC EKIS TLSC ENKI ISFK EMNP PDNI KDTK SDII FFQR SVPG HDNK MQFE SSSY EGYF LACE KERD LFKL ILKK EDEL GDRS IMFT VQNE D |
遺伝子ID: | 3606 |
Uniprot: | Q14116 |
セルラーロケーション: | Secreted |
計算された分子量: | 21kDa/22kDa |
観察された分子量: | 23kDa |
同義語: | IL18, IGIF, IL-18, IL-1g, IL1F4 |
バックグラウンド: | The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family. |
UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 11q22.2-q22.3 Cellular Component: extracellular space; extracellular region; cytosol Molecular Function:protein binding; cytokine activity Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response |
NCBI Summary: | The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] |
UniProt Code: | Q14116 |
NCBI GenInfo Identifier: | 3219817 |
NCBI Gene ID: | 3606 |
NCBI Accession: | Q14116.1 |
UniProt Secondary Accession: | Q14116,O75599, Q6FGY3, Q6WWJ7, |
UniProt Related Accession: | Q14116 |
Molecular Weight: | 21,896 Da |
NCBI Full Name: | Interleukin-18 |
NCBI Synonym Full Names: | interleukin 18 |
NCBI Official Symbol: | IL18 |
NCBI Official Synonym Symbols: | IGIF; IL-18; IL-1g; IL1F4 |
NCBI Protein Information: | interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor) |
UniProt Protein Name: | Interleukin-18 |
UniProt Synonym Protein Names: | Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma |
Protein Family: | Interleukin |
UniProt Gene Name: | IL18 |
UniProt Entry Name: | IL18_HUMAN |