Anti-HLA-DOA Antibody (CAB15277)
- SKU:
- CAB15277
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-HLA-DOA Antibody |
抗体コード: | CAB15277 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-217 of human HLA-DOA (NP_002110.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse lung, Mouse thymus, Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-217 of human HLA-DOA (NP_002110.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TKAD HMGS YGPA FYQS YGAS GQFT HEFD EEQL FSVD LKKS EAVW RLPE FGDF ARFD PQGG LAGI AAIK AHLD ILVE RSNR SRAI NVPP RVTV LPKS RVEL GQPN ILIC IVDN IFPP VINI TWLR NGQT VTEG VAQT SFYS QPDH LFRK FHYL PFVP SAED VYDC QVEH WGLD APLL RHWE LQVP IPPP DAME |
遺伝子ID: | 3111 |
Uniprot: | P06340 |
セルラーロケーション: | Endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
計算された分子量: | 27kDa |
観察された分子量: | 28kDa |
同義語: | HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha |
バックグラウンド: | HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. |
UniProt Protein Function: | HLA-DOA: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endosome membrane; integral to membrane; lysosomal membrane; MHC class II protein complex; plasma membrane Molecular Function:MHC class II receptor activity; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; regulation of T cell differentiation; signal transduction |
NCBI Summary: | HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008] |
UniProt Code: | P06340 |
NCBI GenInfo Identifier: | 122210 |
NCBI Gene ID: | 3111 |
NCBI Accession: | P06340.1 |
UniProt Secondary Accession: | P06340,Q58HU0, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8 Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3, |
UniProt Related Accession: | P06340 |
Molecular Weight: | 27,599 Da |
NCBI Full Name: | HLA class II histocompatibility antigen, DO alpha chain |
NCBI Synonym Full Names: | major histocompatibility complex, class II, DO alpha |
NCBI Official Symbol: | HLA-DOA |
NCBI Official Synonym Symbols: | HLADZ; HLA-DNA; HLA-DZA |
NCBI Protein Information: | HLA class II histocompatibility antigen, DO alpha chain |
UniProt Protein Name: | HLA class II histocompatibility antigen, DO alpha chain |
UniProt Synonym Protein Names: | MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA |
Protein Family: | HLA class II histocompatibility antigen |
UniProt Gene Name: | HLA-DOA |
UniProt Entry Name: | DOA_HUMAN |
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