Anti-Estrogen Related Receptor alpha Antibody (CAB4176)
- SKU:
- CAB4176
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-Estrogen Related Receptor alpha Antibody |
抗体コード: | CAB4176 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Estrogen Related Receptor alpha |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, 293T, Mouse brain |
免疫原: | A synthesized peptide derived from human Estrogen Related Receptor alpha |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2101 |
Uniprot: | P11474 |
セルラーロケーション: | |
計算された分子量: | 55kDa |
観察された分子量: | 50KDa |
同義語: | ERR1, ERRa, ERRalpha, ESRL1, NR3B1 |
バックグラウンド: | The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] |
UniProt Protein Function: | ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor Chromosomal Location of Human Ortholog: 11q13 Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleolus; nucleus Molecular Function:protein domain specific binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding Biological Process: transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; intracellular receptor-mediated signaling pathway; regulation of osteoblast differentiation; organelle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; cartilage development; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] |
UniProt Code: | P11474 |
NCBI GenInfo Identifier: | 215274146 |
NCBI Gene ID: | 2101 |
NCBI Accession: | P11474.3 |
UniProt Related Accession: | P11474 |
Molecular Weight: | |
NCBI Full Name: | Steroid hormone receptor ERR1 |
NCBI Synonym Full Names: | estrogen related receptor alpha |
NCBI Official Symbol: | ESRRA |
NCBI Official Synonym Symbols: | ERR1; ERRa; ESRL1; NR3B1; ERRalpha |
NCBI Protein Information: | steroid hormone receptor ERR1 |
UniProt Protein Name: | Steroid hormone receptor ERR1 |
UniProt Synonym Protein Names: | Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1 |
Protein Family: | Enolase-related protein |
UniProt Gene Name: | ESRRA |
UniProt Entry Name: | ERR1_HUMAN |