Anti-Erlin-2 Antibody (CAB8314)
- SKU:
- CAB8314
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | ERLIN2 Rabbit Polyclonal Antibody |
抗体コード: | CAB8314 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-152 of human ERLIN2 (NP_001003790.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-937, U-251MG |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-152 of human ERLIN2 (NP_001003790.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KIEE GHIG VYYR GGAL LTST SGPG FHLM LPFI TSYK SVQT TLQT DEVK NVPC GTSG GVMI YFDR IEVV NFLV PNAV YDIV KNYT ADYD KALI FNKI HHEL NQFC SVHT LQEV YIEL FGLE NDFS QESS |
遺伝子ID: | 11160 |
Uniprot: | O94905 |
セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
計算された分子量: | 16kDa/22kDa/37kDa |
観察された分子量: | 38kDa |
同義語: | ERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, erlin-2 |
バックグラウンド: | This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1, 4, 5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
UniProt Protein Function: | SPFH2: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; lipid raft; plasma membrane; protein complex Molecular Function:cholesterol binding; protein binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway Disease: Spastic Paraplegia 18, Autosomal Recessive |
NCBI Summary: | This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | O94905 |
NCBI GenInfo Identifier: | 38257366 |
NCBI Gene ID: | 11160 |
NCBI Accession: | O94905.1 |
UniProt Secondary Accession: | O94905,Q6NW21, Q86VS6, Q86W49, A0JLQ1, A8K5S9, B4DM38 D3DSW0, |
UniProt Related Accession: | O94905 |
Molecular Weight: | 22,939 Da |
NCBI Full Name: | Erlin-2 |
NCBI Synonym Full Names: | ER lipid raft associated 2 |
NCBI Official Symbol: | ERLIN2 |
NCBI Official Synonym Symbols: | NET32; SPFH2; SPG18; C8orf2; Erlin-2 |
NCBI Protein Information: | erlin-2 |
UniProt Protein Name: | Erlin-2 |
UniProt Synonym Protein Names: | Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2 |
Protein Family: | Erlin |
UniProt Gene Name: | ERLIN2 |
UniProt Entry Name: | ERLN2_HUMAN |
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