Anti-EDF1 Antibody (CAB2283)[KO Validated]
- SKU:
- CAB2283
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
抗体名: | Anti-EDF1 Antibody [KO Validated] |
抗体コード: | CAB2283 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human EDF1 (NP_003783.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, Mouse brain, Mouse liver, Rat brain, NIH/3T3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human EDF1 (NP_003783.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAES DWDT VTVL RKKG PTAA QAKS KQAI LAAQ RRGE DVET SKKW AAGQ NKQH SITK NTAK LDRE TEEL HHDR VTLE VGKV IQQG RQSK GLTQ KDLA TKIN EKPQ VIAD YESG RAIP NNQV LGKI ERAI GLKL RGKD IGKP IEKG PRAK |
遺伝子ID: | 8721 |
Uniprot: | O60869 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 15kDa/16kDa |
観察された分子量: | 16kDa |
同義語: | EDF1, CFAP280, EDF-1, MBF1 |
バックグラウンド: | This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | EDF1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding; Nuclear receptor co-regulator; RNA-binding Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: transcription factor TFIID complex; cytoplasm; nucleolus; intracellular; nucleus Molecular Function:calmodulin binding; methyltransferase activity; protein binding; histone acetyltransferase activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity Biological Process: endothelial cell differentiation; regulation of lipid metabolic process; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of DNA binding |
UniProt Code: | O60869 |
NCBI GenInfo Identifier: | 62510569 |
NCBI Gene ID: | |
NCBI Accession: | O60869.1 |
Molecular Weight: | ~ 16kDa |
NCBI Full Name: | Endothelial differentiation-related factor 1 |
UniProt Protein Name: | Endothelial differentiation-related factor 1 |
UniProt Synonym Protein Names: | Multiprotein-bridging factor 1; MBF1 |
Protein Family: | Endothelial differentiation-related factor |
UniProt Gene Name: | EDF1 |
UniProt Entry Name: | EDF1_HUMAN |