Anti-DKK1 Antibody (CAB0567)
- SKU:
- CAB0567
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DKK1
- Synonyms:
- DKK-1
- Synonyms:
- SK
Description
| 抗体名: | DKK1 Rabbit pAb |
| 抗体コード: | CAB0567 |
| サイズ: | 20uL, 100uL |
| 同義語: | DKK1, DKK-1, SK |
| 申し込み: | WB, IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human DKK1 |
| 申し込み: | WB, IHC |
| 推奨される希釈: | WB 1:200 - 1:500 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, Jurkat, U-87MG, MCF7, Mouse heart |
| 免疫原: | Recombinant protein of human DKK1 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 22943 |
| Uniprot: | O94907 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 36kDa |
| UniProt Protein Function: | DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. |
| UniProt Protein Details: | Protein type:Inhibitor; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: early endosome membrane; extracellular region; extracellular space; plasma membrane Molecular Function:growth factor activity; low-density lipoprotein receptor binding; protein binding; receptor antagonist activity; signal transducer activity Biological Process: negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of synaptogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; regulation of endodermal cell fate specification; regulation of receptor internalization |
| NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O94907 |
| NCBI GenInfo Identifier: | 13124053 |
| NCBI Gene ID: | 22943 |
| NCBI Accession: | O94907.1 |
| UniProt Secondary Accession: | O94907,B2RC19, |
| UniProt Related Accession: | O94907 |
| Molecular Weight: | 28,672 Da |
| NCBI Full Name: | Dickkopf-related protein 1 |
| NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 1 |
| NCBI Official Symbol: | DKK1 |
| NCBI Official Synonym Symbols: | SK; DKK-1 |
| NCBI Protein Information: | dickkopf-related protein 1 |
| UniProt Protein Name: | Dickkopf-related protein 1 |
| UniProt Synonym Protein Names: | SK |
| Protein Family: | Dickkopf-related protein |
| UniProt Gene Name: | DKK1 |
| UniProt Entry Name: | DKK1_HUMAN |
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