Anti-c-Myc Antibody (CAB11911)

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SKU:

CAB11911

Product type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

MRTL

Synonyms:

MYCC

Synonyms:

bHLHe39

Synonyms:

c-Myc

Synonyms:

MYC

Description

Description

UniProt Protein Function:	Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
UniProt Protein Details:	Protein type:DNA-binding; Nucleolus; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 8q24.21 Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol Molecular Function:protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis Disease: Burkitt Lymphoma
NCBI Summary:	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P01106
NCBI GenInfo Identifier:	127619
NCBI Gene ID:	4609
NCBI Accession:	P01106.1
UniProt Secondary Accession:	P01106,P01107, Q14026, A8WFE7,
UniProt Related Accession:	P01106
Molecular Weight:	439
NCBI Full Name:	Myc proto-oncogene protein
NCBI Synonym Full Names:	v-myc avian myelocytomatosis viral oncogene homolog
NCBI Official Symbol:	MYC
NCBI Official Synonym Symbols:	MRTL; MYCC; c-Myc; bHLHe39
NCBI Protein Information:	myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor
UniProt Protein Name:	Myc proto-oncogene protein
UniProt Synonym Protein Names:	Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family:	Myc protein
UniProt Gene Name:	MYC
UniProt Entry Name:	MYC_HUMAN

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