Anti-BTK Antibody (CAB1576)
- SKU:
- CAB1576
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
抗体名: | Anti-BTK Antibody |
抗体コード: | CAB1576 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-240 of human BTK (NP_000052.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-240 of human BTK (NP_000052.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FLLT VHKL SYYE YDFE RGRR GSKK GSID VEKI TCVE TVVP EKNP PPER QIPR RGEE SSEM EQIS IIER FPYP FQVV YDEG PLYV FSPT EELR KRWI HQLK NVIR YNSD LVQK YHPC FWID GQYL CCSQ TAKN AMGC QILE NRNG SLKP GSSH RKTK KPLP PTPE EDQI LKKP LPPE PAAA PVST SELK KVVA LYDY MPMN ANDL QLRK GDE |
遺伝子ID: | 695 |
Uniprot: | Q06187 |
セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
計算された分子量: | 76kDa/79kDa |
観察された分子量: | Refer to Figures |
同義語: | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, BTK |
バックグラウンド: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Tec family Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; mast cell granule; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:ATP binding; identical protein binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity Biological Process: adaptive immune response; apoptosis; cell maturation; histamine secretion by mast cell; I-kappaB kinase/NF-kappaB cascade; immune system process; innate immune response; negative regulation of cytokine production; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription, DNA-dependent; response to organic substance; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q06187 |
NCBI GenInfo Identifier: | 547759 |
NCBI Gene ID: | 695 |
NCBI Accession: | Q06187.3 |
UniProt Secondary Accession: | Q06187,Q61365, |
UniProt Related Accession: | Q06187 |
Molecular Weight: | |
NCBI Full Name: | Tyrosine-protein kinase BTK |
NCBI Synonym Full Names: | Bruton tyrosine kinase |
NCBI Official Symbol: | BTK |
NCBI Official Synonym Symbols: | AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1 |
NCBI Protein Information: | tyrosine-protein kinase BTK |
UniProt Protein Name: | Tyrosine-protein kinase BTK |
UniProt Synonym Protein Names: | Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; Kinase EMB |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | Btk |
UniProt Entry Name: | BTK_MOUSE |