Anti-Bax Mouse Monoclonal Antibody (CAB2211)

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SKU:
CAB2211
Product type:
Antibody
Reactivity:
Human
Reactivity:
Monkey
Host Species:
Mouse
Isotype:
IgG
Research Area:
Cell Death
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-Bax Mouse Monoclonal Antibody
抗体コード:CAB2211
抗体サイズ:100µL
申し込み:WB
反応性:Human, Monkey
宿主種:Mouse
免疫原:Recombinant protein of human BAX
申し込み:WB
推奨希釈:WB 1:500 - 1:1000
反応性:Human, Monkey
ポジティブサンプル:COS-7, Raji, HeLa
免疫原:Recombinant protein of human BAX
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:581
Uniprot:Q07812
セルラーロケーション:Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein
計算された分子量:4kDa/12kDa/15kDa/18kDa/19kDa/21kDa/24kDa
観察された分子量:21kDa
同義語:BCL2L4, BAX
バックグラウンド:The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
UniProt Protein Function:Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
NCBI Summary:The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q07812
NCBI GenInfo Identifier:728945
NCBI Gene ID:581
NCBI Accession:Q07812.1
UniProt Secondary Accession:Q07812,P55269, Q07814, Q07815, Q8WZ49, Q9NR76, Q9NYG7 Q9UCZ6, Q9UCZ7, Q9UQD6, A8K4W1,
UniProt Related Accession:Q07812
Molecular Weight:19,718 Da
NCBI Full Name:Apoptosis regulator BAX
NCBI Synonym Full Names:BCL2 associated X, apoptosis regulator
NCBI Official Symbol:BAX  
NCBI Official Synonym Symbols:BCL2L4  
NCBI Protein Information:apoptosis regulator BAX
UniProt Protein Name:Apoptosis regulator BAX
UniProt Synonym Protein Names:Bcl-2-like protein 4; Bcl2-L-4
Protein Family:Protein
UniProt Gene Name:BAX  
UniProt Entry Name:BAX_HUMAN
Anti-Bax Mouse Monoclonal Antibody (CAB2211)Western blot analysis of extracts of various cell lines, using BAX antibody (CAB2211) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) (CABS003) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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