Anti-ATPase WRNIP1 Antibody (CAB9170)
- SKU:
- CAB9170
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-ATPase WRNIP1 Antibody |
抗体コード: | CAB9170 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DKAV DTLA YLSD GDAR AGLN GLQL AVLA RLSS RKMF CKKS GQSY SPSR VLIT ENDV KEGL QRSH ILYD RAGE EHYN CISA LHKS MRGS DQNA SLYW LARM LEGG EDPL YVAR RLVR FASE DIGL ADPS ALTQ AVAA YQGC HFIG MPEC EVLL AQCV VYFA RAPK SIEV YSAY NNVK ACLR NHQG PLPP VPLH LRNA PTRL MKDL GYGK GYKY NPMY SEPV DQEY LPEE LRGV DFFK QRRC |
遺伝子ID: | 56897 |
Uniprot: | Q96S55 |
セルラーロケーション: | Nucleus |
計算された分子量: | 31kDa/49kDa/69kDa/72kDa |
観察された分子量: | 72kDa |
同義語: | WRNIP1, WHIP, bA420G6.2 |
バックグラウンド: | Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. |
UniProt Protein Function: | WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation. |
UniProt Protein Details: | Protein type:Helicase; EC 3.6.1.3 Chromosomal Location of Human Ortholog: 6p25.2 Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm Molecular Function:ATPase activity; identical protein binding; protein binding Biological Process: DNA synthesis during DNA repair; regulation of DNA replication initiation |
NCBI Summary: | Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q96S55 |
NCBI GenInfo Identifier: | 73622085 |
NCBI Gene ID: | 56897 |
NCBI Accession: | Q96S55.2 |
UniProt Secondary Accession: | Q96S55,Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681 Q9NRJ6, B2RDB0, |
UniProt Related Accession: | Q96S55 |
Molecular Weight: | 31,339 Da |
NCBI Full Name: | ATPase WRNIP1 |
NCBI Synonym Full Names: | Werner helicase interacting protein 1 |
NCBI Official Symbol: | WRNIP1 |
NCBI Official Synonym Symbols: | WHIP; bA420G6.2 |
NCBI Protein Information: | ATPase WRNIP1 |
UniProt Protein Name: | ATPase WRNIP1 |
UniProt Synonym Protein Names: | Werner helicase-interacting protein 1 |
UniProt Gene Name: | WRNIP1 |
UniProt Entry Name: | WRIP1_HUMAN |
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