Anti-ARHGEF1 Antibody (CAB4274)[KO Validated]
- SKU:
- CAB4274
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ARHGEF1 Antibody [KO Validated] |
抗体コード: | CAB4274 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | HeLa, Jurkat, LO2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PLLS SSEN GNGG RETS PADA RTER ILSD LLPF CRPG PEGQ LAAT ALRK VLSL KQLL FPAE EDNG AGPP RDGD GVPG GGPL SPAR TQEI QENL LSLE ETMK QLEE LEEE FCRL RPLL SQLG GNSV PQPG CT |
遺伝子ID: | 9138 |
Uniprot: | Q92888 |
セルラーロケーション: | Cytoplasm, Membrane |
計算された分子量: | 98kDa/102kDa/104kDa/105kDa |
観察された分子量: | 102kDa |
同義語: | ARHGEF1, GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 |
バックグラウンド: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. |
UniProt Protein Function: | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92888 |
NCBI GenInfo Identifier: | 34395524 |
NCBI Gene ID: | 9138 |
NCBI Accession: | Q92888.2 |
UniProt Secondary Accession: | Q92888,O00513, Q6NX52, Q8N4J4, Q96BF4, Q96F17, Q9BSB1 |
UniProt Related Accession: | Q92888 |
Molecular Weight: | 105,854 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 1 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 1 |
NCBI Official Symbol: | ARHGEF1 |
NCBI Official Synonym Symbols: | LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF |
NCBI Protein Information: | rho guanine nucleotide exchange factor 1 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 1 |
UniProt Synonym Protein Names: | 115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5 |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF1 |
UniProt Entry Name: | ARHG1_HUMAN |
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