Anti-ADK Antibody (CAB15024)
- SKU:
- CAB15024
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ADK Antibody |
抗体コード: | CAB15024 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-345 of human ADK (NP_001114.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-345 of human ADK (NP_001114.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PFIS QFYK ESLM KVMP YVDI LFGN ETEA ATFA REQG FETK DIKE IAKK TQAL PKMN SKRQ RIVI FTQG RDDT IMAT ESEV TAFA VLDQ DQKE IIDT NGAG DAFV GGFL SQLV SDKP LTEC IRAG HYAA SIII RRTG CTFP EKPD FH |
遺伝子ID: | 132 |
Uniprot: | P55263 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 34kDa/36kDa/38kDa/40kDa |
観察された分子量: | Refer to figures |
同義語: | ADK, AK |
バックグラウンド: | This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ADK: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Defects in ADK are the cause of hypermethioninemia due to adenosine kinase deficiency (HMAKD). A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. Belongs to the carbohydrate kinase PfkB family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, other; Nucleotide Metabolism - purine; EC 2.7.1.20 Chromosomal Location of Human Ortholog: 10q22|10q11-q24 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:adenosine kinase activity Biological Process: purine salvage; ribonucleoside monophosphate biosynthetic process Disease: Hypermethioninemia Due To Adenosine Kinase Deficiency |
NCBI Summary: | This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | P55263 |
NCBI GenInfo Identifier: | 6840802 |
NCBI Gene ID: | 132 |
NCBI Accession: | P55263.2 |
UniProt Secondary Accession: | P55263,O00741, O00742, Q16710, Q5JQ10, Q5JQ11, Q9BTN2 B7Z783, B7Z800, |
UniProt Related Accession: | P55263 |
Molecular Weight: | 36,580 Da |
NCBI Full Name: | Adenosine kinase |
NCBI Synonym Full Names: | adenosine kinase |
NCBI Official Symbol: | ADK |
NCBI Official Synonym Symbols: | AK |
NCBI Protein Information: | adenosine kinase |
UniProt Protein Name: | Adenosine kinase |
UniProt Synonym Protein Names: | Adenosine 5'-phosphotransferase |
UniProt Gene Name: | ADK |
UniProt Entry Name: | ADK_HUMAN |
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