ANO1 Antibody (PACO18708)
- SKU:
- PACO18708
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ANO1 Antibody (PACO18708) |
抗体コード: | PACO18708 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human ANO1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO18708(ANO1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18708(ANO1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid, multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events. |
シノニム: | anoctamin 1, calcium activated chloride channel |
UniProt Protein Function: | ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: apical plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane Molecular Function:protein binding; protein homodimerization activity; intracellular calcium activated chloride channel activity; protein heterodimerization activity; calcium activated cation channel activity Biological Process: regulation of membrane potential; multicellular organismal development; chloride transport; transmembrane transport; cation transport |
UniProt Code: | Q5XXA6 |
NCBI GenInfo Identifier: | 74708278 |
NCBI Gene ID: | 55107 |
NCBI Accession: | Q5XXA6.1 |
UniProt Secondary Accession: | Q5XXA6,Q8IYY8, Q8N7V3, A8KAM3, |
UniProt Related Accession: | Q5XXA6 |
Molecular Weight: | |
NCBI Full Name: | Anoctamin-1 |
NCBI Synonym Full Names: | anoctamin 1, calcium activated chloride channel |
NCBI Official Symbol: | ANO1 |
NCBI Official Synonym Symbols: | DOG1; TAOS2; ORAOV2; TMEM16A |
NCBI Protein Information: | anoctamin-1; Ca2+-activated Cl- channel; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains) |
UniProt Protein Name: | Anoctamin-1 |
UniProt Synonym Protein Names: | Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 |
Protein Family: | Anoctamin |
UniProt Gene Name: | ANO1 |
UniProt Entry Name: | ANO1_HUMAN |
Antibodies |
Anti-ANO1 Antibody (CAB10498) |
Anti-ANO1 Antibody (CAB16540) |
ANO1 Antibody (PACO04683) |
ANO1 Antibody (PACO07740) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |