ANAPC5 Antibody (PACO31908)
- SKU:
- PACO31908
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ANAPC5 Antibody (PACO31908) |
抗体コード: | PACO31908 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Anaphase-promoting complex subunit 5 protein (2-232AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO31908 at dilution of 1:100. |
バックグラウンド: | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. |
シノニム: | Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5), ANAPC5, APC5 |
UniProt Protein Function: | APC5: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC5 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol Molecular Function:protein phosphatase binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
NCBI Summary: | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008] |
UniProt Code: | Q9UJX4 |
NCBI GenInfo Identifier: | 37537861 |
NCBI Gene ID: | 51433 |
NCBI Accession: | Q9UJX4.2 |
UniProt Secondary Accession: | Q9UJX4,Q8N4H7, Q9BQD4, E9PFB2, |
UniProt Related Accession: | Q9UJX4 |
Molecular Weight: | 72,526 Da |
NCBI Full Name: | Anaphase-promoting complex subunit 5 |
NCBI Synonym Full Names: | anaphase promoting complex subunit 5 |
NCBI Official Symbol: | ANAPC5 |
NCBI Official Synonym Symbols: | APC5 |
NCBI Protein Information: | anaphase-promoting complex subunit 5; cyclosome subunit 5 |
UniProt Protein Name: | Anaphase-promoting complex subunit 5 |
UniProt Synonym Protein Names: | Cyclosome subunit 5 |
UniProt Gene Name: | ANAPC5 |
UniProt Entry Name: | APC5_HUMAN |