UniProt Protein Function: | APC10: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC10 family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 4q31 Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
NCBI Summary: | ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011] |
UniProt Code: | Q9UM13 |
NCBI GenInfo Identifier: | 119625457 |
NCBI Gene ID: | 10393 |
NCBI Accession: | EAX05052 |
UniProt Secondary Accession: | Q9UM13,Q2V500, Q9UG51, Q9Y5R0, D3DNZ7, |
UniProt Related Accession: | Q9UM13 |
Molecular Weight: | 21,252 Da |
NCBI Full Name: | anaphase promoting complex subunit 10, isoform CRA_b |
NCBI Synonym Full Names: | anaphase promoting complex subunit 10 |
NCBI Official Symbol: | ANAPC10 |
NCBI Official Synonym Symbols: | DOC1; APC10 |
NCBI Protein Information: | anaphase-promoting complex subunit 10 |
UniProt Protein Name: | Anaphase-promoting complex subunit 10 |
UniProt Synonym Protein Names: | Cyclosome subunit 10 |
Protein Family: | Anaphase-promoting complex |
UniProt Gene Name: | ANAPC10 |
UniProt Entry Name: | APC10_HUMAN |