AKR1D1 Antibody, HRP conjugated (PACO24848)
- SKU:
- PACO24848
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | AKR1D1 Antibody, HRP conjugated (PACO24848) |
抗体コード: | PACO24848 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human 3-oxo-5-beta-steroid 4-dehydrogenase protein (1-200AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid, intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates. |
シノニム: | 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Aldo-keto reductase family 1 member D1) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase), AKR1D1, SRD5B1 |
UniProt Protein Function: | AKR1D1: Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. Defects in AKR1D1 are the cause of congenital bile acid synthesis defect type 2 (CBAS2); also known as cholestasis with delta(4)-3-oxosteroid 5-beta-reductase deficiency. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine. Belongs to the aldo/keto reductase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - primary bile acid biosynthesis; Lipid Metabolism - androgen and estrogen; Oxidoreductase; EC 1.3.1.3; Lipid Metabolism - C21-steroid hormone Chromosomal Location of Human Ortholog: 7q32-q33 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; steroid binding Biological Process: androgen metabolic process; bile acid biosynthetic process; C21-steroid hormone metabolic process; cholesterol catabolic process; digestion Disease: Bile Acid Synthesis Defect, Congenital, 2 |
NCBI Summary: | The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010] |
UniProt Code: | P51857 |
NCBI GenInfo Identifier: | 1703007 |
NCBI Gene ID: | 6718 |
NCBI Accession: | P51857.1 |
UniProt Secondary Accession: | P51857,A1L4P6, A8K060, B4DPN3, B4DPN8, |
UniProt Related Accession: | P51857 |
Molecular Weight: | 32,890 Da |
NCBI Full Name: | 3-oxo-5-beta-steroid 4-dehydrogenase |
NCBI Synonym Full Names: | aldo-keto reductase family 1, member D1 |
NCBI Official Symbol: | AKR1D1 |
NCBI Official Synonym Symbols: | CBAS2; SRD5B1; 3o5bred |
NCBI Protein Information: | 3-oxo-5-beta-steroid 4-dehydrogenase |
UniProt Protein Name: | 3-oxo-5-beta-steroid 4-dehydrogenase |
UniProt Synonym Protein Names: | Aldo-keto reductase family 1 member D1; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase |
Protein Family: | 3-oxo-5-beta-steroid 4-dehydrogenase |
UniProt Gene Name: | AKR1D1 |
UniProt Entry Name: | AK1D1_HUMAN |