AIM2 Antibody (PACO47290)
- SKU:
- PACO47290
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | AIM2 Antibody (PACO47290) |
抗体コード: | PACO47290 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: AIM2 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39 kDa. Observed band size: 39, 45 kDa.. | |
Immunofluorescent analysis of A549 cells using PACO47290 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47290 at dilution of 1:100. |
バックグラウンド: | Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 β and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. |
シノニム: | Interferon-inducible protein AIM2 (Absent in melanoma 2), AIM2 |
UniProt Protein Function: | AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 1q22 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; protein binding; double-stranded DNA binding Biological Process: positive regulation of interleukin-1 beta production; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; immune response; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor |
NCBI Summary: | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14862 |
NCBI GenInfo Identifier: | 5902751 |
NCBI Gene ID: | 9447 |
NCBI Accession: | O14862.1 |
UniProt Secondary Accession: | O14862,Q5T3V9, Q96FG9, A8K7M7, |
UniProt Related Accession: | O14862 |
Molecular Weight: | 343 |
NCBI Full Name: | Interferon-inducible protein AIM2 |
NCBI Synonym Full Names: | absent in melanoma 2 |
NCBI Official Symbol: | AIM2 |
NCBI Official Synonym Symbols: | PYHIN4 |
NCBI Protein Information: | interferon-inducible protein AIM2 |
UniProt Protein Name: | Interferon-inducible protein AIM2 |
UniProt Synonym Protein Names: | Absent in melanoma 2 |
Protein Family: | Protein |
UniProt Gene Name: | AIM2 |
UniProt Entry Name: | AIM2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |