AIFM3 Antibody (PACO15808)
- SKU:
- PACO15808
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | AIFM3 Antibody (PACO15808) |
抗体コード: | PACO15808 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human AIFM3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15808(AIFM3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO15808(AIFM3 Antibody) at dilution 1/290, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15808(AIFM3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | AIFL (apoptosis-inducing factor-like), also known as AIFM3 (apoptosis-inducing factor, mitochondrion-associated, 3), is a 605 amino acid, protein that localizes to the mitochondrion and contains one rieske domain. Expressed ubiquitously in tissues including liver, thymus, ovary, bone marrow and cerebral cortex, AIFL functions to induce apoptosis, specifically through a caspase-dependent pathway, and may also play a role in the modulation of mitochondrial membrane potential. Multiple isoforms of AIFL exist due to alternative splicing events. The gene encoding AIFL maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. |
シノニム: | apoptosis-inducing factor, mitochondrion-associated, 3 |
UniProt Protein Function: | AIFM3: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Belongs to the FAD-dependent oxidoreductase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Mitochondrial; Apoptosis; EC 1.-.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; nucleus Molecular Function:2 iron, 2 sulfur cluster binding; FAD binding; metal ion binding; oxidoreductase activity Biological Process: cell redox homeostasis |
UniProt Code: | Q96NN9 |
NCBI GenInfo Identifier: | 74732608 |
NCBI Gene ID: | 150209 |
NCBI Accession: | Q96NN9.1 |
UniProt Secondary Accession: | Q96NN9,Q6ZT44, Q8N1V3, Q8N5E0, B7WP37, D3DX37, D3DX38 |
UniProt Related Accession: | Q96NN9 |
Molecular Weight: | 65,966 Da |
NCBI Full Name: | Apoptosis-inducing factor 3 |
NCBI Synonym Full Names: | apoptosis-inducing factor, mitochondrion-associated, 3 |
NCBI Official Symbol: | AIFM3 |
NCBI Official Synonym Symbols: | AIFL |
NCBI Protein Information: | apoptosis-inducing factor 3; apoptosis-inducing factor like |
UniProt Protein Name: | Apoptosis-inducing factor 3 |
UniProt Synonym Protein Names: | Apoptosis-inducing factor-like protein |
Protein Family: | Apoptosis-inducing factor |
UniProt Gene Name: | AIFM3 |
UniProt Entry Name: | AIFM3_HUMAN |