ADAMTS4 Antibody, HRP conjugated (PACO24768)
- SKU:
- PACO24768
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ADAMTS4 Antibody, HRP conjugated (PACO24768) |
抗体コード: | PACO24768 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 protein (213-319AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu- |-Ala-393' site. |
シノニム: | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1), ADAMTS4, KIAA0688 |
UniProt Protein Function: | ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Protease; Secreted; EC 3.4.24.82 Chromosomal Location of Human Ortholog: 1q21-q23 Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region Molecular Function:peptidase activity; protein binding; protease binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development |
NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75173 |
NCBI GenInfo Identifier: | 317373445 |
NCBI Gene ID: | 9507 |
NCBI Accession: | O75173.3 |
UniProt Secondary Accession: | O75173,Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83, |
UniProt Related Accession: | O75173 |
Molecular Weight: | 90,197 Da |
NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
NCBI Official Symbol: | ADAMTS4 |
NCBI Official Synonym Symbols: | ADMP-1; ADAMTS-2; ADAMTS-4 |
NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 |
UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
UniProt Synonym Protein Names: | ADMP-1; Aggrecanase-1 |
Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
UniProt Gene Name: | ADAMTS4 |
UniProt Entry Name: | ATS4_HUMAN |