ACMSD Antibody, HRP conjugated (PACO53531)
- SKU:
- PACO53531
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ACMSD Antibody, HRP conjugated (PACO53531) |
抗体コード: | PACO53531 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase protein (33-129AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. |
シノニム: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase), ACMSD |
UniProt Protein Function: | ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 4.1.1.45; Amino Acid Metabolism - tryptophan; Lyase Chromosomal Location of Human Ortholog: 2q21.3 Cellular Component: cytosol Molecular Function:aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding Biological Process: quinolinate metabolic process; tryptophan catabolic process |
NCBI Summary: | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] |
UniProt Code: | Q8TDX5 |
NCBI GenInfo Identifier: | 37999723 |
NCBI Gene ID: | 130013 |
NCBI Accession: | Q8TDX5.1 |
UniProt Secondary Accession: | Q8TDX5,Q3B7X3, Q53SR5, Q96KY2, |
UniProt Related Accession: | Q8TDX5 |
Molecular Weight: | 31,213 Da |
NCBI Full Name: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
NCBI Synonym Full Names: | aminocarboxymuconate semialdehyde decarboxylase |
NCBI Official Symbol: | ACMSD |
NCBI Protein Information: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase |
UniProt Protein Name: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
UniProt Synonym Protein Names: | Picolinate carboxylase |
Protein Family: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
UniProt Gene Name: | ACMSD |
UniProt Entry Name: | ACMSD_HUMAN |