ABI1 Antibody (PACO07533)
- SKU:
- PACO07533
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ABI1 Antibody (PACO07533) |
抗体コード: | PACO07533 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human ABI1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | 507aa,55kd; |
UniProt Protein Function: | Abi-1: an SH3-containing adapter protein that regulates c-Abl-mediated phosphorylation of Mena. Binds the SH3 domains of epidermal growth factor receptor kinase substrate (EPS8) and of spectrin. May play a role in fusion of macropinocytic vesicles. Associated with congenital acute monocytic leukemia. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10p11.2 Cellular Component: postsynaptic membrane; growth cone; cytoskeleton; endoplasmic reticulum; lamellipodium; postsynaptic density; intracellular; nucleus; cytosol; cell junction; filopodium Molecular Function:protein binding; cytoskeletal protein binding; protein complex binding; protein tyrosine kinase activator activity Biological Process: negative regulation of cell proliferation; somitogenesis; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; innate immune response; cell motility; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q8IZP0 |
NCBI GenInfo Identifier: | 50400546 |
NCBI Gene ID: | 10006 |
NCBI Accession: | Q8IZP0.4 |
UniProt Related Accession: | Q8IZP0 |
Molecular Weight: | 55kDa |
NCBI Full Name: | Abl interactor 1 |
NCBI Synonym Full Names: | abl interactor 1 |
NCBI Official Symbol: | ABI1 |
NCBI Official Synonym Symbols: | E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1 |
NCBI Protein Information: | abl interactor 1 |
UniProt Protein Name: | Abl interactor 1 |
UniProt Synonym Protein Names: | Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1 |
Protein Family: | Abl interactor |
UniProt Gene Name: | ABI1 |
UniProt Entry Name: | ABI1_HUMAN |