ABCE1 Antibody (PACO15223)
- SKU:
- PACO15223
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ABCE1 Antibody (PACO15223) |
抗体コード: | PACO15223 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human ABCE1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, human ovarian cancer tissue, Primary antibody: PACO15223(ABCE1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. |
シノニム: | ATP-binding cassette, sub-family E (OABP), member 1 |
UniProt Protein Function: | ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q31 Cellular Component: mitochondrion; membrane; cytoplasm Molecular Function:ATPase activity; iron-sulfur cluster binding; ribonuclease inhibitor activity; ATP binding Biological Process: viral reproduction; response to virus; RNA catabolic process; negative regulation of catalytic activity |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61221 |
NCBI GenInfo Identifier: | 108773784 |
NCBI Gene ID: | 6059 |
NCBI Accession: | NP_001035809.1 |
UniProt Secondary Accession: | P61221,O88793, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10 Q99K66, |
UniProt Related Accession: | P61221 |
Molecular Weight: | Calculated: 67kDaObserved: 67kDa |
NCBI Full Name: | ATP-binding cassette sub-family E member 1 |
NCBI Synonym Full Names: | ATP-binding cassette, sub-family E (OABP), member 1 |
NCBI Official Symbol: | ABCE1 |
NCBI Official Synonym Symbols: | RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI |
NCBI Protein Information: | ATP-binding cassette sub-family E member 1 |
UniProt Protein Name: | ATP-binding cassette sub-family E member 1 |
UniProt Synonym Protein Names: | 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I |
Protein Family: | ABC transporter E family |
UniProt Gene Name: | ABCE1 |
UniProt Entry Name: | ABCE1_HUMAN |