SLC26A3 Antibody (PACO02102)
- SKU:
- PACO02102
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| 抗体名: | SLC26A3 Antibody |
| 抗体コード: | PACO02102 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the C-terminal region of human DRA. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | SLC26A3; DRA; Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 |
| UniProt Protein Function: | SLC26A3: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q31 Cellular Component: membrane; brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function:bicarbonate transmembrane transporter activity; protein binding; chloride transmembrane transporter activity; transporter activity; anion:anion antiporter activity; secondary active sulfate transmembrane transporter activity; transcription cofactor activity; transcription factor activity Biological Process: intracellular pH elevation; regulation of transcription, DNA-dependent; bicarbonate transport; membrane hyperpolarization; ion transport; excretion; transmembrane transport; anion transport; sperm capacitation Disease: Diarrhea 1, Secretory Chloride, Congenital |
| NCBI Summary: | The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P40879 |
| NCBI GenInfo Identifier: | 729367 |
| NCBI Gene ID: | 1811 |
| NCBI Accession: | P40879.1 |
| UniProt Related Accession: | P40879 |
| Molecular Weight: | 764 |
| NCBI Full Name: | Chloride anion exchanger |
| NCBI Synonym Full Names: | solute carrier family 26 (anion exchanger), member 3 |
| NCBI Official Symbol: | SLC26A3 |
| NCBI Official Synonym Symbols: | CLD; DRA |
| NCBI Protein Information: | chloride anion exchanger; down-regulated in adenoma protein; solute carrier family 26, member 3 |
| UniProt Protein Name: | Chloride anion exchanger |
| UniProt Synonym Protein Names: | Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 |
| Protein Family: | Chloride anion exchanger |
| UniProt Gene Name: | SLC26A3 |
| UniProt Entry Name: | S26A3_HUMAN |