LIN9 Antibody (PACO60080)
- SKU:
- PACO60080
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LIN9 Antibody (PACO60080) |
抗体コード: | PACO60080 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
反応性: | Human |
免疫原: | Recombinant Human Protein lin-9 homolog protein (5-103AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO60080 diluted at 1:800 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. |
シノニム: | Protein lin-9 homolog (HuLin-9) (hLin-9) (β subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor β chain-associated protein) (pRB-associated protein), LIN9, BARA TGS |
UniProt Protein Function: | LIN9: a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1. Three alternative spliced human isoforms have been reported. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Transcription, coactivator/corepressor; Tumor suppressor Chromosomal Location of Human Ortholog: 1q42.12 Cellular Component: nucleoplasm Molecular Function:protein binding Biological Process: regulation of cell cycle |
NCBI Summary: | This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q5TKA1 |
NCBI GenInfo Identifier: | 74708186 |
NCBI Gene ID: | 286826 |
NCBI Accession: | Q5TKA1.1 |
UniProt Secondary Accession: | Q5TKA1,Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1, |
UniProt Related Accession: | Q5TKA1 |
Molecular Weight: | 57,733 Da |
NCBI Full Name: | Protein lin-9 homolog |
NCBI Synonym Full Names: | lin-9 DREAM MuvB core complex component |
NCBI Official Symbol: | LIN9 |
NCBI Official Synonym Symbols: | TGS; BARA; TGS1; TGS2; Lin-9; BARPsv |
NCBI Protein Information: | protein lin-9 homolog |
UniProt Protein Name: | Protein lin-9 homolog |
UniProt Synonym Protein Names: | Beta subunit-associated regulator of apoptosis; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; pRB-associated protein |
Protein Family: | Protein |
UniProt Gene Name: | LIN9 |
UniProt Entry Name: | LIN9_HUMAN |